In Week 6 of the college football season, more teams across the country are kicking off their conference schedule, including three matches between AP Top 25 teams.

Hendon Hooker and the #8 Tennessee Volunteers start the matchup with an SEC matchup with the #25 LSU Tigers, while #17 TCU, fresh from an upset victory over Oklahoma, takes on the undefeated #19 Kansas at Lawrence. The final ranking match of the weekend is a PAC-12 showdown between No. 11 Utah and No. 18 UCLA. Chip Kelly’s Bruins could be a surprise contender in the conference after beating Washington last Friday.

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But what games should gamers be on the lookout for this weekend?

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We have everything you need to make your betting decisions up to week 6.

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Check out all the betting and trending notes courtesy of Sportzshala Stats & Information.


No. 4 Michigan in Indiana (-22, 59)
12:00 pm ET, Memorial Stadium, Bloomington.

  • Indiana has been 0-6 ATS and SU against ranked opponents since the start of last season.

  • Michigan are 12-4 ATS favorites since the start of last season and 4-1 ATS favorites on the road in the same period.

  • Michigan has been 9-3 ATS since the start of last season as a double-digit favorite since early 2021, tied with Georgia for 2nd most covers as a double-digit favorite in this span (ALA-11).

  • Indiana has been ranked 2-9 in Big Ten games since the start of the 2021 season.

No. 8 Tennessee (-2.5, 64) for 25 LSU
12:00 pm ET on Sportzshala, Tiger Stadium (LA), Baton Rouge, Los Angeles.

  • LSU is 3-0 ATS at home this season and 4-0-1 ATS in their last five games as a home underdog.

  • Four out of five LSU games this season have ended in failure.

  • LSU 3-1 ATS vs top 10 AP teams over last two seasons.

  • Tennessee is 3-0 ATS in the last 3 games as a favorite on the road, but 0-3 ATS in the last 3 conference games.

#17 TCU (-7, 67.5) at No. 19 Kansas
12:00 pm ET, David Booth Memorial Stadium in Kansas, Lawrence.

  • Kansas is one of only five FBS teams to go 5-0 ATS this season.

  • Kansas opened the +30,000 season to win the Big 12, the biggest odds of any team. From their 5-0 start to the season, they jumped to +1200, 6th in the conference.

  • TCU is 3-0 ATS as the favorite this season, while Kansas is 3-0 ATS as the underdog.

  • All of TCU’s last four games against ranked opponents are over.

Arkansas 23rd in Mississippi (-8, 62)
12:00 pm ET on SEC Network, Davis Wade Stadium, Starkville.

  • Arkansas is 10-4-1 ATS in their last 15 games against AP-rated opponents.

  • Arkansas is 7-2-1 ATS in their last 10 road games.

  • 11 of the last 15 meetings between these two teams have ended.

  • Mississippi State last played on a ranked team in Week 5 of 2020 against Arkansas. MSST was 17 points behind and failed to cover.

Texas in Oklahoma (-7.65)
12:00 pm ET on ABC, Cotton Bowl, Dallas.

  • Texas is 4-1 ATS in their last five games as the favorite.

  • Oklahoma hit after losses, with 16 games more since the start of the 2012 season and only three games fewer since a loss.

  • In their last 10 meetings against Oklahoma, Texas 7-3 ATS.

  • Oklahoma has failed to cover in their last three Big 12 games, but all three have topped the total.

Auburn at number 2 in Georgia (-29.5, 50)
3:30 pm ET, Sanford Stadium, Athens.

  • Georgia is 0-5 ATS in their last five games as a home favorite.

  • All five games played by Georgia this season went under the total. Virginia Tech is the only other team to have 5 games this season.

  • Georgia has been 8-1 against Auburn since 2014.

Texas Institute of Technology ranked 7th in Oklahoma (-9.5, 57.5)
3:30 pm ET, Boone Pickens Stadium, Stillwater.

  • Texas Tech 5-1 ATS vs. Oklahoma State since 2016.

  • Oklahoma State is 6-1-1 ATS in their last eight games as the home favorite.

  • Since the start of last season, Oklahoma State has been 9-0-1 ATS in conference games.

  • Since the start of the 2012 season, Texas Tech games against AP top 10 opponents have been played more than 10 times and less than three times.

No. 11 Utah (-4.5, 64) at No. 18 UCLA
3:30 pm ET Rose Bowl, Pasadena

  • Utah 5-0 ATS when facing UCLA since 2016.

  • Utah are 4-0 by the ATS in their last 4 games as favorites and have been 4-0 against AP-ranked rivals since the start of last season.

  • UCLA is 4-1 in their last 5 games as a home underdog.

No. 9 Ole Miss in Vanderbilt (-18.5, 59.5)
3:30 p.m. ET FirstBank Stadium, Nashville

  • Since the start of last season, Vanderbilt has been 1-4 ATS against ranked opponents.

  • Since the beginning of last season, Ole Miss has played a total of 9 conferences, of which 1 is more and 8 is less.

  • On the other hand, Vanderbilt has seen four out of five games this season top the total, with only one losing. This ties them with Arkansas for the most games in the SEC this season.

  • Vanderbilt is 5-0 ATS in their last five games since the loss.

No. 20 Kansas State (-2, 45.5) in Iowa
4:00 pm ET at SportzshalaU, Jack Trice Stadium, Ames

  • Iowa State has been 0-5 ATS against ranked opponents since the start of last season.

  • Kansas State is 4-1 on the ATS this season, tied for 3rd in the Big 12.

  • Iowa State is 0-3 ATS when the line is within field goal limits (-3 to +3) since the start of last season.

  • Iowa State is 4-0 ATS as a home underdog since the start of the 2018 season.

No. 3 Ohio in Michigan (-25.5, 63)
4:00 pm ET on ABC, Spartan Stadium, East Lansing.

  • Michigan Street is down 0-3 this season.

  • Michigan State has a 0–3 ATS against the top 5 AP teams since 2019 and a 1–6 ATS against the top 10 AP teams over the same period.

  • Ohio State has been 5-0 against Michigan Street since the start of the 2017 season.

  • While the last meeting between the two teams in week 13 last season fell through, Ohio State has played all 3 games of their conference since they ended.

Washington State No. 6 USC (-13, 66)
7:30 pm ET, Los Angeles Memorial Coliseum, Los Angeles

  • Washington State is 4-1 by the ATS this season, making them the best Pac-12 coverage percentage this season.

  • Washington State has led 9-2 conference games since the start of last season.

  • Washington State is 7-1 ATS in their last 8 games as an underdog.

  • Since the start of 2017, USC has been 7-15-1 ATS as a double-digit favorite.

No. 16 BYU at Notre Dame (-3.5, 52)
7:30 pm ET, Allegiant Stadium, Las Vegas.

  • Notre Dame is 12-5 ATS against ranked opponents since 2018.

  • BYU has failed to cover in their last 3 games after covering in their first 2 games this season.

  • All three of Notre Dame’s last games after the farewell week were below the total.

Army No. 15 Wake Forest (-17, 67.5)
7:30 pm ET on Sportzshala3, Truist Field, Winston-Salem

  • This season, Wake Forest is 4-1 in ATS, tied with Syracuse for the best ATS record of any ACC team this season.
    Wake Forest is a 7-4-1 ATS favorite since the start of last season.
    The Army is 1-5 ATS in their last six non-conference games.
    Army has played eight games against ranked opponents since 2014, seven of which have been lower and just one higher.

No. 5 Clemson (-20.5, 50) at Boston College
7:30 pm ET on ABC, Alumni Stadium, Chestnut Hill.

  • Clemson is 2-8 ATS as a double-digit favorite since the start of the 2021 season.

  • Since starting the 2021 season with a 0-5 ATS in conference games, Clemson has gone 5-1 ATS in his last 6 ACC matches.

  • Since the start of the 2017 season, BC has been a 10-5-1 ATS as a home underdog.

  • This season BC has 1-4 ATS which is the worst ATS record in the ACC.

Florida State 14th in North Carolina (-3.5, 52)
8:00 pm ET on the ACC network, Carter-Finley Stadium, Raleigh.

  • North Carolina State is 6-0 ATS after losing since the start of the 2020 season.

  • Since the start of the 2005 season, North Carolina State has been 14-3 ATS against Florida State.

  • Florida State is 4-0 ATS in their last four games as an underdog and 3-0 ATS in their last three road games.

  • North Carolina State has had four consecutive ACC games, the longest conference game streak since the 2009 season.

Texas A&M at no. 1 Alabama (-24, 51.5)
8:00 pm ET, Bryant-Denny Stadium, Tuscaloosa.

  • Texas A&M 8-4 ATS (3-9 SU) vs No. 1 AP rated teams since 2000 They faced Alabama seven times when Alabama ranked first in that range, going 5-2 ATS (2-5 SS)

  • Alabama is so far 3-0 ATS at home this season.

  • In games played for the AP No.1 team under Nick Saban, Alabama is 54-40-2 ATS.

  • The last four meetings between TA&M and ALA ended back in the 2018 season.

No. 12 Oregon (-13, 70.5) in Arizona
9:00 pm ET, Arizona Stadium, Tucson.

  • Oregon has seen their last four games come to an end however since 2012 they have had seven games against Arizona and only 1 in that period.

  • Oregon is 1-4 ATS in their last five games as the away favorite.

  • Arizona is 0-3 ATS in their last three games as a double-digit underdog, but 4-1 ATS in their last five as a home underdog.